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Modular-Lab PharmTracer

Your solution for efficient routine production and research of radiopharmaceuticals

Modular-Lab PharmTracer is your solution for efficient routine production of radiopharmaceuticals and research. It uses disposable cassettes containing all the necessary components for a particular synthesis. By customizing the synthesis cassettes and adapting the projects in the software new tracers and processes can easily be developed.

Please note: We have optimized our Modular-Lab PharmTracer for the use of 18F-Tracers. New software templates and new cassettes are available for 18F-FDG, 18F-NaF, 18F-FET,  18F-FLT, 18F-FMISO and 18F-PSMA-1007. For more information please download the overview of available F-18 systems below.

Detail Information

The laboratory equipment Modular-Lab PharmTracer has been specifically designed to allow versatile and efficient routine production of different tracers, complying with GMP requirements. The concept of disposable cassettes enables the user to easily label different radionuclides with the same setup, but without the risk of cross contamination.
The system retains the reliability and versatility of the Modular-Lab Standard system, allowing to make changes in the process as necessary during early-stage development, but then “lock-in” the process for routine production. With this addition, Modular-Lab PharmTracer is the ideal platform for development as well as production of radiopharmaceuticals.

Setup for theranostic tracers and more
The Modular-Lab PharmTracer setup for the labeling of 68Ga-, 111In-, 177Lu- and 90Y-DOTA peptides will be combined with a Heater Reaction Module (HRM), a Syringe Module (SYM) and, if necessary, with an additional 1-fold Module (SLM-1) when performing the a presure test before the synthesis. Sterile disposable cassettes ensure easy handling by click‘n’start technology. The easy-to-program intuitive graphical interface of the Modular-Lab software is used to control or adapt the synthesis process.

Setup for 18F tracers
By simply adding modules the setup can be rearranged for use with 18F tracers. Using the cartridge-based SPE purification approach, the basic Fluorine-18 PharmTracer setup, consisting of the Heater Module (HRM), the Syringe Module (SYM), the 4-fold Module (SLM-4), the 2-fold Module (SLM-2) and a vacuum pump, will enable the production of [18F]FDG, [18F]FET, [18F]FLT, [18F]FMISO and [18F]PSMA-1007. A heater and SLM-4 will not be required when producing [18F]NaF.

Further setups
Further combinations allow the production of 11C, 64Cu and other tracers. More detailed information can be provided upon request.

Sterile Disposable Cassettes
All cassettes are assembled under GMP-compliant clean room conditions, sterilized with gamma-radiation and double-vacuum-packed. The consumables used are chemical resistant and have been tested for their suitability with the specific syntheses. A shelf life of 18 months can be guaranteed. Cartridges are included and preconditioned automatically if necessary. Due to the cassettes one-time use no cleaning, drying or sanitation routines are necessary.

Take a brief look into our cassette production department here.

Modular-Lab PharmTracer is based on a unique, modular approach combining the speed and safety of a remote, fully-automated system with the option to configure syntheses for novel tracers. The GMP-manufactured sterile disposable cassettes avoid intense cleaning and sanitation routines. The synthesis process is programmed by Eckert & Ziegler Eurotope making additional programming dispensable. Modular-Lab PharmTracer’s multifunctionality supports routine production of 18F-, 11C-, 68Ga-, 111In-, 177Lu- and 90Y-DOTA peptides.
The setup can also be combined with an analytical HPLC and TLC. The intuitive user interface complies with GMP, cGMP, GLP and GAMP 5 requirements. Parameters such as temperature, activity detector readings, flow rates, or valve settings can be monitored easily in one window. Reports containing all relevant data and information are created automatically after each run. In addition, a cost and space efficient alternative to the conventional electrical cabinet (EC) is now available for specific systems with low power consumption. It consists of the EC mini in combination with the software Modular-Lab SoftPLC.


Apart from this versatile system, Eckert & Ziegler also offers additional alternatives from the Modular-Lab family. Modular-Lab Standard uses a tubing-based approach and has been specifically designed for research and development of radiotracers, whereas Modular-Lab eazy provides a space and cost efficient solution for cassette-based routine production of Theranostics tracers. With KitLab we offer a stand-alone solution for automated cold kit labeling and more.

Recent Publications


Spreckelmeyer S – Fully-automated production of [68Ga]Ga-FAPI-46 for clinical application (link)

Heing‐Becker I – A Cyanine‐Bridged Somatostatin Hybrid Probe for Multimodal SSTR2 Imaging in Vitro and in Vivo: Synthesis and Evaluation (link)


Hofstetter M – Effect of the versatile bifunctional chelator AAZTA5 on the radiometal labelling properties and the in vitro performance of a gastrin releasing peptide receptor antagonist (link)

Jussing E – [68Ga]ABY-028: an albumin-binding domain (ABD) protein-based imaging tracer for positron emission tomography (PET) studies of altered vascular permeability and predictions of albumin-drug conjugate transport (link)

Mansi R – A new 68Ga-labeled somastostatin analog containing two iodo-amino acids for dual somatostatin receptor subtype 2 and 5 targeting (link)

Wagner M – Automated GMP-Compliant Production of [68Ga]Ga-DO3A-Tuna-2 for PET Microdosing Studies of the Glucagon Receptor in Humans (link)

Velikyan I – GMP production of [68Ga]Ga-BOT5035 for Imaging of liver fibrosis in microdosing phase 0 study (link)

Vidal A – ARRONAX Cyclotron: Setting up of In-House Hospital Radiopharmacy (link)

Spreckelmeyer S – Fully-automated production of [68Ga]Ga-PentixaFor on the module Modular Lab-PharmTracer (link)


Van der Veen E – Clinical-grade N-(4-[18F]fluorobenzoyl)-interleukin-2 for PET imaging of activated T-cells in humans (link)

Velikyan I – Diagnostic HER2-binding radiopharmaceutical, [68Ga]Ga-ABY-025, for routine clinical use in breast cancer patients (link)

Von Hacht J L – Increasing molar activity by HPLC purification improves 68Ga-DOTA-NAPamide tumor accumulation in a B16/F1 melanoma xenograft model (link)

Erdmann S – CMKLR1-targeting peptide tracers for PET/MR imaging of breast cancer (link)


Gnesin S – First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist 68Ga-NODAGA-MJ9 (link)

Willowson KP – Feasibility and accuracy of single time point imaging for renal dosimetry following 177Lu-DOTATATE (‘Lutate’) therapy (link)

Nielsen KM – Preclinical evaluation of potential infection-imaging probe [68Ga]Ga-DOTA-K-A9 in sterile and infectious inflammation (link)

Käkelä M – Adventures in radiosynthesis of clinical grade [68Ga]Ga-DOTA-Siglec-9 (link)

Sanchez-Crespo A – Hallmarks in prostate cancer imaging with Ga68-PSMA-11-PET/CT with reference to detection limits and quantitative properties (link)

Menda Y – 90Y-DOTATOC Dosimetry–Based Personalized Peptide Receptor Radionuclide Therapy (link)


Eckert & Ziegler
Eurotope GmbH
Robert-Rössle-Strasse 10
13125 Berlin
Fax: +49 30 94 10 84 470

Your contact in US and Canada

Eckert & Ziegler
Radiopharma, Inc.
25 Upton Drive
Wilmington, MA 01887
Fax: + 1 508 497 0061

Get in touch

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