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Lutetium-177 (n.c.a.)

Radiochemical for non-clinical research purposes

Eckert & Ziegler Radiopharma GmbH offers carrier-free [177Lu]Lutetium Chloride solution for your research activities. The radiochemical solution is used for the preparation of radiolabeled compounds in the non-clinical research context.

Lutetium-177 n.c.a is currently only available in non-GMP research grade. Our teams are working on the provision of GMP grade [177Lu]Lutetium Chloride solution. Use the contact form at the end of the page to get in touch and find out more.

Detail Information

Lutetium-177 is a β-emitter with a half-life of 6.65 days. It can be produced via two different routes, direct by irradiation of Lutetium-176 for carrier-added or indirect by irradiation of Ytterbium-176 for non-carrier-added form. Lutetium-177 decays by emission of beta radiation (β: Emax= 498 keV) and gamma radiation (γ: 208 keV – 10.3 % abundance) to Hafnium-177.

Background
Lutetium-177 has become more and more important over the last years as a substance used in many new radiopharmaceuticals, especially for cancer therapy. In combination with diagnostic [68Ga]-based-agents it is now the main therapeutic nuclide for theranostic approaches such as with DOTA-conjugated compounds for binding on the prostate specific membrane antigen (PSMA). A large number of further radiotherapeutic agents are currently under development for several types of cancer.

Method and Specifications
Eckert & Ziegler offers Lutetium-177 in high quality no-carrier-added (n.c.a.) / carrier-free form. [177Lu]Lutetium Chloride Solution is produced by irradiation of Ytterbium-176 ([176Yb]) and subsequent separation of [177Lu] in our radiochemical facility. This process achieves highest purity.

Specifications
Table - Eckert & Ziegler Lu-177 Chloride Solution Specifications

Shipping and Calibration
Eckert & Ziegler offers high flexibility regarding calibration time and date. A pre-calibration up to seven days is possible.
Lutetium-177 will be delivered within four business days worldwide.

Timeline

Since March 2020, Eckert & Ziegler is supplying [177Lu]Lutetium Chloride solution to selected customers for non-clinical research. We are continuously expanding our production to provide additional batches to further customers. Furthermore, we plan to have Lutetium-177 in GMP quality available in 2021.

 

Timeline Lu-177

 

For further information please refer to the specification sheet or contact us through the contact form below.

Eckert & Ziegler Radiopharma offers a wide range of radionuclides for chemical or pharmaceutical use, from Actinium-225 via Gallium-68 to Yttrium-90.

Contact

Eckert & Ziegler
Radiopharma GmbH
Robert-Rössle-Straße 10
13125 Berlin
Germany
Fax: +49 30 941084 470

Get in touch

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