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Flow-Count

radio-HPLC detection system

The Flow-Count is a radioisotope HPLC detection system, which is compatible with most liquid chromatography systems. It uses specially configured photomultipliers and/or PIN diode detectors to detect gamma positron and high-energy beta emitters at both high and low levels of activity. Flow-Count is ideally suited for PET tracer analysis of 18F and 11C.

Detail Information

Technology
Flow-Count eliminates the need for fraction collection and scintillation counting. It is a flexible and easy-to-use system. Background interference is reduced with variable energy window settings and sensitivity is optimized with adjustable flow cell volumes. Miniature detectors can fit into small locations and can operate up to 12 feet away from the base unit, making shielding easier. Several detector holders and flow cells are available to suit your particular application requirements. A standard 0 to 1 volt analog signal or optional extended range module is used to connect Flow-Count to your existing chromatography data system. Alternatively, interface the digital TTL pulse signal with RaPET Chromatography Software for maximum sensitivity, dynamic range, and optional cGMP and 21 CFR Part 11 compliance.

Holders and flow cells
A variety of detector holders and flow cells are easily adapted to a wide range of applications. Since the flow cells are made of inexpensive standard Teflon tubing, the flow cells are disposable should they become contaminated. All of our flow cells have variable volumes, which can be set by the user.

Applications

  • Radiopharmaceutical purity analysis (99mTc, 111In, 125I, 123I, 131I, 90Y)
  • HPLC analysis of 125I and 32P labeled compounds
  • Monoclonal antibody labeling and analysis (125I, 131I, 90Y)
  • Protein and DNA labeling and analysis (32P, 125I)
  • PET tracer analysis (18F, 11C)

Flow-Count can also be used with PET Metabolite for dual coincidence detection.

 

Eckert & Ziegler also provides a GMP-compliant option of this HPLC-detection system.

Recent Publications

2020

White JM – Removal of Fc Glycans from [89Zr]Zr-DFO-Anti-CD8 Prevents Peropheral Depletion of CD8+ T Cells (link)

2018

Basuli F – Rapid synthesis of maleimide functionalized fluorine‐18 labeled prosthetic group using “radio‐fluorination on the Sep‐Pak” method (link)

Contact

Eckert & Ziegler
Eurotope GmbH
Robert-Rössle-Strasse 10
13125 Berlin
Germany
Fax: +49 30 94 10 84 470

Your contact in US and Canada

Eckert & Ziegler
Radiopharma, Inc.
25 Upton Drive
Wilmington, MA 01887
USA
Fax: + 1 508 497 0061

Get in touch

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